On January 3, 1882, Oscar Wilde, a twenty-seven-year-old genius at least by his own reckoning arrived in New York. The Dublin-born Oxford man had made such a spectacle of himself in London with his eccentric fashion sense, acerbic wit, and extravagant passion for art and home design that Gilbert & S[...]

This is the fourth edition of a very successful textbook on clinical trials methodology, written by three recognized experts who have long and extensive experience in all areas of clinical trials. Most chapters have been revised considerably from the third edition. A chapter on ethics has been added[...]